Sensor Review, Volume 35, Issue 2, March 2015.
Purpose Real time monitoring of wound or injured tissues is critical for speedy recovery and onset of cascade of biochemical reactions provide potential biomarkers which facilitate the process of wound monitoring e.g. pH, temperature, moisture level, bacterial load, cytokine and interleukins etc. Among all the biomarkers, pH has been known to have profound impact on wound healing process and it helps determine the incidence of bacterial infection in the wound (persistent elevated alkaline pH), proteolytic activity at the site of injury, take-rate in skin grafting, wound healing stage and preparation of wound debridement. Design/methodology/approach This review highlights the significance of pH in determination of clinical parameters and selection of appropriate treatment regime and it presents in depth analysis of the designs and fabrication methods of integrated pH sensors which have been reported till to date for the real time monitoring of wound healing. Findings For expedited wound healing process, significance of pH mandated the need of integrated sensor system which facilitates the real time monitoring of healing wounds and obviates the requirement of redressing or complicated testing procedures which are labor intensive and also painful for patient. Different types of sensor systems have been discussed in this review which were developed using hydrogel as pH responsive system coupled with voltammetry, potentiometry, impedimetric and flex-circuit inductive transducer systems. All of the mentioned devices have considerable potential for clinical applications and there is need of in vivo testing to validate their efficiency and sensitivity under practical scenarios Originality/value This manuscript is original review of literature and the permision request has been sent to use figures from other published papers
Purpose Real time monitoring of wound or injured tissues is critical for speedy recovery and onset of cascade of biochemical reactions provide potential biomarkers which facilitate the process of wound monitoring e.g. pH, temperature, moisture level, bacterial load, cytokine and interleukins etc. Among all the biomarkers, pH has been known to have profound impact on wound healing process and it helps determine the incidence of bacterial infection in the wound (persistent elevated alkaline pH), proteolytic activity at the site of injury, take-rate in skin grafting, wound healing stage and preparation of wound debridement. Design/methodology/approach This review highlights the significance of pH in determination of clinical parameters and selection of appropriate treatment regime and it presents in depth analysis of the designs and fabrication methods of integrated pH sensors which have been reported till to date for the real time monitoring of wound healing. Findings For expedited wound healing process, significance of pH mandated the need of integrated sensor system which facilitates the real time monitoring of healing wounds and obviates the requirement of redressing or complicated testing procedures which are labor intensive and also painful for patient. Different types of sensor systems have been discussed in this review which were developed using hydrogel as pH responsive system coupled with voltammetry, potentiometry, impedimetric and flex-circuit inductive transducer systems. All of the mentioned devices have considerable potential for clinical applications and there is need of in vivo testing to validate their efficiency and sensitivity under practical scenarios Originality/value This manuscript is original review of literature and the permision request has been sent to use figures from other published papers